Typhus vaccination

Vaccine

In Germany there are several vaccines. They are either oral live vaccines (capsules to be swallowed) or vaccines to be injected.

Typherix®
Composition: 1 dose (0.5 ml) contains: Vi-Polysaccharide of Salmonella typhi. 25 μg.
Further additives: sodium dihydrogen phosphate, Sodium monohydrogen phosphate, Sodiumchlorid, Phenol 1.1 mg, water for the purpose of injection

TYPHiM Vi®
Composition: 1 dose (0.5 ml) contains: purified Vi-capsule polysaccharide of Salmonella typhi (strain Ty 2) 25 μg.
Further additives: Phenol, buffered isotonic saline solution

Typhoral L® capsules
Composition: 1 capsule contains: Salmonella typhi, strain Ty 21 a Berna at least. 1 billion apathogenic live germs and at least 5 billion inactivated germs.

Further additives: salt, vitamins, saccharine.

Immunity

Oral vaccinations have only a very minimal protective effect of 33-67%, when vaccines are injected they are 55-74%(Plotkin S.A., Bouveret-Le Cam N.: A new typhoid vaccine composed of the Vi capsular polysaccharide. Arch Intern Med 1995, 155(21):2293-2299)

Vaccine complications and vaccine damages

Typherix® adverse effects: local reactions (reddening, swelling, pain). General reaction (e.g. headache, elevated temperature, malaise)

Allergic reactions: rare.

TYPHiM Vi® Side effects: Local reactions (reddening, swelling, pain). General reactions (e.g. headaches, elevated temperature, malaise). Allergic reactions (rare). Myalgia, nausea, diarrhea, vomiting, joint pain. For booster shots increased occurrence of local side effects possible.

Typhoral L® Side effects: Local reactions (reddening, swelling, pain). General reactions (e.g. headache, elevated temperature, malaise). Allergic reactions (rare). Very rare intestinal problems and general reactions such as elevated temperature, chills, headaches and joint pain. Very rare exanthema.